The Overlapping Community Structure of Structural Brain Network in Young Healthy Individuals
نویسندگان
چکیده
Community structure is a universal and significant feature of many complex networks in biology, society, and economics. Community structure has also been revealed in human brain structural and functional networks in previous studies. However, communities overlap and share many edges and nodes. Uncovering the overlapping community structure of complex networks remains largely unknown in human brain networks. Here, using regional gray matter volume, we investigated the structural brain network among 90 brain regions (according to a predefined anatomical atlas) in 462 young, healthy individuals. Overlapped nodes between communities were defined by assuming that nodes (brain regions) can belong to more than one community. We demonstrated that 90 brain regions were organized into 5 overlapping communities associated with several well-known brain systems, such as the auditory/language, visuospatial, emotion, decision-making, social, control of action, memory/learning, and visual systems. The overlapped nodes were mostly involved in an inferior-posterior pattern and were primarily related to auditory and visual perception. The overlapped nodes were mainly attributed to brain regions with higher node degrees and nodal efficiency and played a pivotal role in the flow of information through the structural brain network. Our results revealed fuzzy boundaries between communities by identifying overlapped nodes and provided new insights into the understanding of the relationship between the structure and function of the human brain. This study provides the first report of the overlapping community structure of the structural network of the human brain.
منابع مشابه
Brain Structural Covariance Network in Asperger Syndrome Differs From Those in Autism Spectrum Disorder and Healthy Controls
Introduction: Autism is a heterogeneous neurodevelopmental disorder associated with social, cognitive and behavioral impairments. These impairments are often reported along with alteration of the brain structure such as abnormal changes in the grey matter (GM) density. However, it is not yet clear whether these changes could be used to differentiate various subtypes of autism spectrum disorder ...
متن کاملBrain-Behavioral Systems in Patients with Comorbid Anxiety -Depression vs. Healthy Individuals
Background: According to the brain-behavioral systems theory, behavioral inhibition and behavioral activation systems contribute to the development of many psychopathological conditions. Given that anxiety and depression are the most common emotional disorders and the fact that they are highly overlapping, the aim of this study was to compare the brain-behavioral systems in the...
متن کاملDetecting Overlapping Communities in Social Networks using Deep Learning
In network analysis, a community is typically considered of as a group of nodes with a great density of edges among themselves and a low density of edges relative to other network parts. Detecting a community structure is important in any network analysis task, especially for revealing patterns between specified nodes. There is a variety of approaches presented in the literature for overlapping...
متن کاملOverlapping Community Detection in Social Networks Based on Stochastic Simulation
Community detection is a task of fundamental importance in social network analysis. Community structures enable us to discover the hidden interactions among the network entities and summarize the network information that can be applied in many applied domains such as bioinformatics, finance, e-commerce and forensic science. There exist a variety of methods for community detection based on diffe...
متن کاملInvestigating the functional communication network in patients with knee osteoarthritis using graph-based statistical models
Introduction: Osteoarthritis of the knee is the most prevalent type of arthritis that causes persistent pain and reduces the quality of life. However, no treatment alleviates symptoms or stops the disease from progressing. Functional magnetic resonance imaging (fMRI) studies can provide information on neural mechanisms of pain by assessing correlation patterns among the different regions of the...
متن کامل